Travel by car: the driving distance between Split and Makarska is 65 km and approximately travelling time is 1 hour and 10 minutes. In summer season traffic on this route is quite big, so you can expect that travelling time will be much longer, especially around city Omis.
Travel by bus: Between Split and Makarska there is a good bus connection, current timetable and price tickets you can check here.
Alternative ways of travelling from Split to Makarska:
Travel by train: There is no possibility to travel by train from Split to Makarska.